Invention Grant
- Patent Title: Autoimmune and inflammatory disorder therapy
- Patent Title (中): 自身免疫性和炎症性疾病治疗
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Application No.: US14343416Application Date: 2012-09-07
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Publication No.: US09301961B2Publication Date: 2016-04-05
- Inventor: Jean Herman , Thierry Louat , Qiuya Huang , Bart Vanderhoydonck , Mark Waer , Piet Herdewijn
- Applicant: Jean Herman , Thierry Louat , Qiuya Huang , Bart Vanderhoydonck , Mark Waer , Piet Herdewijn
- Applicant Address: BE Leuven
- Assignee: Katholieke Universiteit Leuven, K.U. Leuven R&D
- Current Assignee: Katholieke Universiteit Leuven, K.U. Leuven R&D
- Current Assignee Address: BE Leuven
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: GB1115665.0 20110909
- International Application: PCT/EP2012/067574 WO 20120907
- International Announcement: WO2013/034738 WO 20130314
- Main IPC: A61K31/426
- IPC: A61K31/426 ; G01N33/564 ; A61K31/5377 ; A61K31/519 ; G01N33/573
Abstract:
Compounds that bind to phosphatidylinositol-4-kinase IIIβ (PI4KIIIβ) and inhibit the binding of PI4KIIIβ to its substrate and/or inhibit PI4KIIIβ activity may be used in the treatment and/or prevention of an autoimmune or inflammatory disorder, or organ or cell transplant rejection. A new assay for identifying compounds for use in treating and/or preventing those pathological conditions, which comprises measuring the inhibition of PI4KIIIβ activity, is also disclosed.
Public/Granted literature
- US20140294870A1 Autoimmune and Inflammatory Disorder Therapy Public/Granted day:2014-10-02
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