Invention Grant
- Patent Title: Methods and compositions for the treatment of insulin-associated medical conditions
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Application No.: US14588945Application Date: 2015-01-04
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Publication No.: US09301981B2Publication Date: 2016-04-05
- Inventor: Eran Hornstein , Tal Melkman-Zehavi , Roni Oren
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K48/00 ; A61K35/39 ; C12N5/071 ; C12N15/113 ; A61K31/713 ; A61K38/46 ; A01K67/027

Abstract:
A method of increasing insulin content in a pancreatic beta cell is disclosed. The method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein the microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-29, miR-30, miR-129, miR-141, miR-148, miR-182, miR-200, miR-376 and Let-7, thereby increasing the insulin content in the pancreatic beta cell.
Public/Granted literature
- US20150125433A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF INSULIN-ASSOCIATED MEDICAL CONDITIONS Public/Granted day:2015-05-07
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