Invention Grant
US09301990B2 Small molecule conjugates for intracellular delivery of biologically active compounds
有权
用于细胞内递送生物活性化合物的小分子缀合物
- Patent Title: Small molecule conjugates for intracellular delivery of biologically active compounds
- Patent Title (中): 用于细胞内递送生物活性化合物的小分子缀合物
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Application No.: US13917524Application Date: 2013-06-13
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Publication No.: US09301990B2Publication Date: 2016-04-05
- Inventor: Philipp Hadwiger , Torsten Hoffmann , Kerstin Jahn-Hofmann , Eric A. Kitas , David L. Lewis , Peter Mohr , Hans Martin Mueller , Guenther Ott , Ingo Roehl , David B. Rozema
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: HOFFMANN-LA ROCHE, INC.
- Current Assignee: HOFFMANN-LA ROCHE, INC.
- Current Assignee Address: US NJ Little Falls
- Agency: Genentech, Inc.
- Agent Alex Andrus
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12Q1/60 ; A61K38/00 ; C12N15/87 ; C07C69/96 ; C07C271/20 ; C12N15/113 ; A61K31/7088 ; A61K47/48 ; A61K48/00 ; C07K7/02
Abstract:
The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.
Public/Granted literature
- US20140135381A1 Small molecule conjugates for intracellular delivery of biologically active compounds Public/Granted day:2014-05-15
Information query
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