Invention Grant
- Patent Title: Compositions comprising a radiosensitizer and an anti-cancer agent and methods of uses thereof
- Patent Title (中): 包含放射增敏剂和抗癌剂的组合物及其使用方法
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Application No.: US13259213Application Date: 2010-04-26
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Publication No.: US09302003B2Publication Date: 2016-04-05
- Inventor: Léon Sanche , Gabriel Charest
- Applicant: Léon Sanche , Gabriel Charest
- Applicant Address: CA Sherbrooke
- Assignee: SOCPRA—SCIENCES SANTÉ´ET HUMAINES
- Current Assignee: SOCPRA—SCIENCES SANTÉ´ET HUMAINES
- Current Assignee Address: CA Sherbrooke
- Agency: Goudreau Gage Dubuc
- Agent Julie Gauvreau
- International Application: PCT/CA2010/000583 WO 20100426
- International Announcement: WO2010/121368 WO 20101028
- Main IPC: A61K41/00
- IPC: A61K41/00 ; A61K9/14 ; A61K9/00 ; A61K9/127 ; A61K31/282 ; A61K33/24 ; A61K45/06
Abstract:
A combination of an anti-cancer agent and a metal radiosensitizer potentiates the radiotherapy of cancer. Said anti-cancer agent is preferably cisplatin while the metal radiosensitizer is preferably gold nanoparticles. Both the anti-cancer agent and the metal radiosensitizer bind to DNA and potentiate the radiotherapy of cancer by synergistically increases the amount of double strand breaks induced by the radiation. The anti-cancer agent and the metal radiosensitizer may be encapsulated in liposomes.
Public/Granted literature
- US20120093918A1 COMPOSITIONS COMPRISING A RADIOSENSITIZER AND AN ANTI-CANCER AGENT AND METHODS OF USES THEREOF Public/Granted day:2012-04-19
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