A child safety and alert system and method that detect and monitor access and egress for assignable locations within a motor vehicle by identifying designated positions within the vehicle, by monitoring at least one of the motor, the driver door and other doors or closures in the vehicle, by activating a timer if the motor is stopped or the driver door is opened and closed, and by triggering an alarm if the designated doors or closures are not opened within a predefined time interval after the motor stops or the driver door is opened. The alarm can be deactivated from the driver seat or by a remote device. The system and method are similarly useful for alerting a driver to retrieve objects from storage locations within a vehicle.