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Invention Grant
US09302992B2 Multifunctional quinoline derivatives as anti-neurodegenerative agents 有权
多功能喹啉衍生物作为抗神经变性剂

Multifunctional quinoline derivatives as anti-neurodegenerative agents
Abstract:
Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases. In one aspect, the invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein R1 is hydrogen, (C1-C8)alkyl, (C1-C8)alkylene(C3-C8)cycloalkyl, (C1-C8)haloalkyl, or (C1-C8)alkylene(C6-C20)aryl; R2 is hydrogen or halogen; R3 is hydrogen, halogen, (C1-C8)alkyl, or (C1-C8)alkoxy; R4 is hydrogen, halogen, (C1-C8)alkyl, (C1-C8)alkoxy, or (C1-C8)haloalkyl; R5 is hydrogen or (C1-C20)alkanol; R6 is hydrogen; and R7 is (C1-C20)alkanol, (C1-C8)alkylene (C3-C8)heterocyclyl(C1-C20)alkanol, (C1-C8)alkylene (C3-C8)heterocyclyl(C1-C20)alkyl, (C1-C8)alkylene(C1-C6)alkylamino(C1-C6)alkynyl, (C1-C8)alkyleneamino(C1-C20)alkanol, or (C1-C8)alkyleneamino(C1-C20)alkanol(C1-C8)alkylene substituted (C3-C20)heteroaryl; (II) or wherein: R1, R2, R3, R4 and R6 are each defined in (I) above; R5 is (C1-C20)alkanol; and R7 is hydrogen, (C1-C20)alkanol, (C1-C8)alkylene (C3-C8)heterocyclyl(C1-C20)alkanol, (C1-C8)alkylene (C3-C8)heterocyclyl(C1-C20)alkyl, (C1-C8)alkylene(C1-C6)alkylamino(C1-C6)alkynyl, (C1-C8)alkyleneamino(C1-C20)alkanol, or (C1-C8)alkyleneamino(C1-C20)alkanol(C1-C8)alkylene substituted (C3-C20)heteroaryl.
Abstract(Chinese):

公开了新的喹啉衍生物。 还公开了其治疗神经变性疾病的合成及其用途。 一方面，本发明涉及式（I）化合物或其药学上可接受的盐：（I）其中R1是氢，（C1-C8）烷基，（C1-C8）亚烷基（C3-C8）环烷基， （C 1 -C 8）卤代烷基或（C 1 -C 8）亚烷基（C 6 -C 20）芳基; R2是氢或卤素; R3是氢，卤素，（C1-C8）烷基或（C1-C8）烷氧基; R4是氢，卤素，（C1-C8）烷基，（C1-C8）烷氧基或（C1-C8）卤代烷基; R5是氢或（C1-C20）链烷醇; R6是氢; 和（C1-C20）烷基，（C1-C20）链烷醇，（C1-C20）链烷醇，（C1-C20） -C 1 -C 8）亚烷基氨基（C 1 -C 8）亚烷基氨基（C 1 -C 8）亚烷基氨基（C 1 -C 8）亚烷基 （C 3 -C 20）杂芳基; （II）或其中：R 1，R 2，R 3，R 4和R 6各自定义在上述（I）中; R5是（C1-C20）烷醇; 并且R 7是氢，（C 1 -C 20）烷醇，（C 1 -C 8）亚烷基（C 3 -C 8）杂环基（C 1 -C 20）链烷醇，（C 1 -C 8）亚烷基（C 3 -C 8） （C1-C8）亚烷基（C1-C8）亚烷基（C1-C6）烷基氨基（C1-C6）炔基，（C1-C8）亚烷基氨基（C1-C20）链烷醇或（C1-C8） 亚烷基取代的（C 3 -C 20）杂芳基。

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