Invention Grant
- Patent Title: Heteroaryl linked quinolinyl modulators of RORγt
- Patent Title (中): 杂芳基连接的喹啉基调节剂RORγt
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Application No.: US14053682Application Date: 2013-10-15
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Publication No.: US09303015B2Publication Date: 2016-04-05
- Inventor: Kristi A. Leonard , Kent Barbay , James P. Edwards , Kevin D. Kreutter , David A. Kummer , Umar Maharoof , Rachel Nishimura , Maud Urbanski , Hariharan Venkatesan , Aihua Wang , Ronald L. Wolin , Craig R. Woods , Anne Fourie , Xiaohua Xue
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE
- Assignee: JANSSEN PHARMACEUTICA NV
- Current Assignee: JANSSEN PHARMACEUTICA NV
- Current Assignee Address: BE
- Agent Yuriy P. Stercho
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D401/14 ; C07D417/14 ; A61K45/06 ; A61K31/4709
Abstract:
The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
Public/Granted literature
- US20140107096A1 HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt Public/Granted day:2014-04-17
Information query
