Invention Grant
US09303042B2 Triazolothienopyrimidine compound inhibitors of urea transporters and methods of using inhibitors
有权
尿素转运蛋白的三唑并噻吩并嘧啶化合物抑制剂和使用抑制剂的方法
- Patent Title: Triazolothienopyrimidine compound inhibitors of urea transporters and methods of using inhibitors
- Patent Title (中): 尿素转运蛋白的三唑并噻吩并嘧啶化合物抑制剂和使用抑制剂的方法
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Application No.: US14388645Application Date: 2013-03-27
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Publication No.: US09303042B2Publication Date: 2016-04-05
- Inventor: Marc Anderson , Alan S. Verkman
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Seed IP Law Group PLLC
- International Application: PCT/US2013/034063 WO 20130327
- International Announcement: WO2013/148813 WO 20131003
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D495/22 ; A61P7/10 ; A61P9/12 ; A61P9/04 ; A61P13/12 ; A61P13/02
Abstract:
Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.
Public/Granted literature
- US20150057274A1 TRIAZOLOTHIENOPYRIMIDINE COMPOUND INHIBITORS OF UREA TRANSPORTERS AND METHODS OF USING INHIBITORS Public/Granted day:2015-02-26
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