Invention Grant
US09303044B2 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders
有权
7-（哌嗪-1-基）-5H- [1,3,4]噻二唑并[3,2-A]嘧啶-5-酮用于治疗血栓形成障碍
![7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders](/docs/US/2016-04-05/US09303044B2/abs.jpg.600x600.jpg)
- Patent Title: 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders
- Patent Title (中): 7-（哌嗪-1-基）-5H- [1,3,4]噻二唑并[3,2-A]嘧啶-5-酮用于治疗血栓形成障碍
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Application No.: US14372488Application Date: 2013-01-16
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Publication No.: US09303044B2Publication Date: 2016-04-05
- Inventor: Barry S. Coller , Craig Thomas , Marta Filizola , Joshua McCoy , Wenwei Huang , Min Shen , Jian-Kang Jiang
- Applicant: The Rockefeller University , The United States of America, as Represented by the Secretary, Department of Health and Human Services , Mount Sinai School of Medicine, Office of Technology and Business Development
- Applicant Address: US DC Washington US NY New York US NY New York
- Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE ROCKEFELLER UNIVERSITY,ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,THE ROCKEFELLER UNIVERSITY,ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US DC Washington US NY New York US NY New York
- Agency: Cantor Colburn LLP
- International Application: PCT/US2013/021749 WO 20130116
- International Announcement: WO2013/109632 WO 20130725
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D471/00 ; C07D487/00 ; C07D491/00 ; C07D513/04 ; A61K45/06 ; A61K31/436 ; A61K31/337 ; A61K31/4353 ; A61K31/727 ; A61L31/02 ; A61L31/10 ; A61L31/16
![7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders](/abs-image/US/2016/04/05/US09303044B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to compounds and compositions of Formula P useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of variables A, B, R2, R3, R4, Ra, Ra′, Rb, Rb′, Rc, Rd, Rd′, Re, and Re′ are provided in the disclosure. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
Public/Granted literature
- US20150050325A1 ORGANIC COMPOUNDS Public/Granted day:2015-02-19
Information query
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