Invention Grant
- Patent Title: Charge conversional ternary polyplex
- Patent Title (中): 充电会话三元polyplex
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Application No.: US14543091Application Date: 2014-11-17
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Publication No.: US09303122B2Publication Date: 2016-04-05
- Inventor: Kazunori Kataoka , Yan Lee , Nobuhiro Nishiyama , Kanjiro Miyata , Makoto Oba , Shigehiro Hiki , Mai Sanjo , HyunJin Kim
- Applicant: THE UNIVERSITY OF TOKYO
- Applicant Address: JP Tokyo
- Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee: THE UNIVERSITY OF TOKYO
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Main IPC: C08G69/48
- IPC: C08G69/48 ; A61K31/7084 ; A61K31/785 ; A61K48/00 ; C08G69/10 ; C08G69/40 ; C12N15/11 ; C12N15/88
Abstract:
Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.
Public/Granted literature
- US20150141575A1 CHARGE CONVERSIONAL TERNARY POLYPLEX Public/Granted day:2015-05-21
Information query
