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US09303245B2 Self-assembling tissue modules 有权
自组装组织模块

Self-assembling tissue modules
Abstract:
The invention relates to a new approach to constructing cellular aggregates in vitro and their use in methods for producing 3D-tissue constructs in a modular way.In particular, the invention is directed to a method for in vitro producing a tissue construct comprising: a) combining living cells to form supracellular aggregates using spatial confinement; b) combining two or more of the supracellular aggregates in a mold or on a biomaterial; c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and d) applying conditions that induce tissue morphogenesis in the tissue construct.
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