Invention Grant
- Patent Title: Self-assembling tissue modules
- Patent Title (中): 自组装组织模块
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Application No.: US12999841Application Date: 2009-06-22
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Publication No.: US09303245B2Publication Date: 2016-04-05
- Inventor: Nicolas Clément Rivron , Jeroen Rouwkema , Roman Truckenmuller , Séverine Le Gac , Clemens Antoni Van Blitterswijk , Erik Jacob Vrij
- Applicant: Nicolas Clément Rivron , Jeroen Rouwkema , Roman Truckenmuller , Séverine Le Gac , Clemens Antoni Van Blitterswijk , Erik Jacob Vrij
- Applicant Address: NL Maastricht
- Assignee: Universiteit Maastricht
- Current Assignee: Universiteit Maastricht
- Current Assignee Address: NL Maastricht
- Agency: TraskBritt
- Priority: EP08158652 20080620
- International Application: PCT/NL2009/050368 WO 20090622
- International Announcement: WO2009/154466 WO 20091223
- Main IPC: C12N13/00
- IPC: C12N13/00 ; C12N5/00 ; C12N5/071 ; C12N5/0775

Abstract:
The invention relates to a new approach to constructing cellular aggregates in vitro and their use in methods for producing 3D-tissue constructs in a modular way.In particular, the invention is directed to a method for in vitro producing a tissue construct comprising: a) combining living cells to form supracellular aggregates using spatial confinement; b) combining two or more of the supracellular aggregates in a mold or on a biomaterial; c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and d) applying conditions that induce tissue morphogenesis in the tissue construct.
Public/Granted literature
- US20110171712A1 SELF-ASSEMBLING TISSUE MODULES Public/Granted day:2011-07-14
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