Invention Grant
- Patent Title: Phased genome sequencing
- Patent Title (中): 分阶段基因组测序
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Application No.: US14330707Application Date: 2014-07-14
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Publication No.: US09303289B2Publication Date: 2016-04-05
- Inventor: Wing H. Wong , Hong Yang
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Edward J. Baba; Shweta Chandra
- Main IPC: C12Q1/68
- IPC: C12Q1/68

Abstract:
The present disclosure provides methods for determining phased nucleic acid sequence for a single chromosome of interest and/or a single chromosomal fragment of interest. The present disclosure also provides methods for determining phased nucleic acid sequence for a plurality of single chromosomes of interest and/or a plurality of single chromosomal fragments of interest. The plurality of single chromosomes of interest may be of one chromosome type or of two or more chromosome types. The present disclosure also provides a method for isolating a plurality of chromosomal fragments of a specified size range, where the chromosomal fragments are from one or more specified regions of the genome. The plurality of chromosomal fragments may be separated into single chromosomal fragments and sequenced to provide phased nucleic acid sequence for the single chromosomal fragments. Alternatively, the plurality of chromosomal fragments may be sequenced together to provide unphased nucleic acid sequence for the chromosomal fragments.
Public/Granted literature
- US20150011409A1 Phased Genome Sequencing Public/Granted day:2015-01-08
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