Invention Grant
US09303292B2 Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles
有权
使用未修饰的金纳米颗粒直接检测未扩增的丙型肝炎病毒RNA
- Patent Title: Direct detection of unamplified hepatitis C virus RNA using unmodified gold nanoparticles
- Patent Title (中): 使用未修饰的金纳米颗粒直接检测未扩增的丙型肝炎病毒RNA
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Application No.: US12987659Application Date: 2011-01-10
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Publication No.: US09303292B2Publication Date: 2016-04-05
- Inventor: Sherif Mohamed Shawky Abduo , Hassan Mohamed El-Said Azzay El-Badawy
- Applicant: Sherif Mohamed Shawky Abduo , Hassan Mohamed El-Said Azzay El-Badawy
- Applicant Address: EG New Cairo
- Assignee: The American University of Cairo
- Current Assignee: The American University of Cairo
- Current Assignee Address: EG New Cairo
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; B82Y15/00
Abstract:
A gold nanoparticle-based colorimetric assay kit for hepatitis C virus RNA that detects unamplified HCV RNA in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to HCV RNA. A method for detecting hepatitis C virus comprising contacting a sample suspected of containing hepatitis C virus with a polynucleotide that binds to hepatitis C virus RNA and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting hepatitis C virus in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red).
Public/Granted literature
- US20130236880A1 DIRECT DETECTION OF UNAMPLIFIED HEPATITIS C VIRUS RNA USING UNMODIFIED GOLD NANOPARTICLES Public/Granted day:2013-09-12
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