A non-rotation lock screw for a wellhead assembly is provided that includes a rotating portion and a non-rotating portion. The non-rotating portion includes a distal end configured to engage a component of the wellhead assembly, and may include one or more seals. The rotating portion may be rotating into a component of wellhead assembly such that the non-rotating portion translates in a radial direction. The rotating portion and non-rotating portion may be coupled together via a bearing to enable free rotation of the rotating portion. Systems and methods of operation that include the non-rotation lock screw are also provided.