A frame assembly for facilitating disassembly of a striker-fired pistol is disclosed. The frame assembly facilitates removal of the slide from a striker-fired pistol without trigger manipulation and with minimized potential for a round to be chambered. The frame assembly includes a takedown safety lever and a takedown actuation lever. Movement of the takedown safety lever causes the sear to be moved such that subsequent slide motion will not result in the storage of striker energy. Movement of the takedown safety lever is only possible while the slide is refracted beyond the point at which a chambered round would be ejected. Removal of the slide does not require pulling the trigger. The positioning of the takedown safety lever motion for disassembly may be precluded by the presence of a magazine in the gun, thereby eliminating the possibility that a round could be chambered during subsequent slide motion.