A method and apparatus for power managed interrupt handling is disclosed. In one embodiment, a system includes one or more agents that may invoke an interrupt request. An interrupt controller is configured to receive and process the interrupt requests. When idle, the interrupt controller may be placed in a low power state. The system also includes an interrupt power control circuit coupled to receive interrupt request indications from each of the one or more agents that may invoke interrupts. The interrupt power control circuit is configured to assert a wakeup signal responsive to receiving an indication of an interrupt request from one of the agents. If the interrupt controller is in a low power state, it may exit the state and resume operation in an active state responsive to assertion of the wakeup signal.