Methods and systems to identify and migrate threads among system nodes based on system performance metrics. An example method disclosed herein includes sampling a performance metric of a computer program thread, the computer program thread executing on a home node of a computer system having multiple nodes, and determining whether the performance metric exceeds a threshold value. The method also includes identifying a remote node associated with a remote memory if the threshold value is exceeded, the remote memory being accessed by the computer program thread, and identifying the computer program thread as a candidate for migration from the home node to the remote node if the threshold value is exceeded. In this way, a computer program thread that frequently accesses a remote memory can be migrated from a home node to a remote node associated with the remote memory to reduce the latency associated with memory accesses performed by the computer program thread and thereby improve system performance.