Invention Grant
US09308236B2 Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
有权
PD-1 / PD-L1和CD80（B7-1）/ PD-L1蛋白/蛋白相互作用的大环抑制剂
- Patent Title: Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
- Patent Title (中): PD-1 / PD-L1和CD80（B7-1）/ PD-L1蛋白/蛋白相互作用的大环抑制剂
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Application No.: US14201977Application Date: 2014-03-10
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Publication No.: US09308236B2Publication Date: 2016-04-12
- Inventor: Michael Matthew Miller , Claudio Mapelli , Martin Patrick Allen , Michael S. Bowsher , Kenneth M. Boy , Eric P. Gillis , David R. Langley , Eric Mull , Maude A. Poirier , Nishith Sanghvi , Li-Qiang Sun , Daniel J. Tenney , Kap-Sun Yeung , Juliang Zhu , Patrick C. Reid , Paul Michael Scola
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Pamela A. Mingo; Stephen C. D'Amico
- Main IPC: C07K7/56
- IPC: C07K7/56 ; A61K38/12 ; C07K7/08 ; G01N33/68 ; A61K38/10 ; A61K39/39 ; A61K45/06 ; G01N33/574 ; A61K38/00
Abstract:
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Public/Granted literature
- US20140294898A1 MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS Public/Granted day:2014-10-02
Information query
