Invention Grant
US09308258B2 Stable and aggregation free antibody FC molecules through CH3 domain interface engineering
有权
稳定和无聚集抗体FC分子通过CH3结构域界面工程
- Patent Title: Stable and aggregation free antibody FC molecules through CH3 domain interface engineering
- Patent Title (中): 稳定和无聚集抗体FC分子通过CH3结构域界面工程
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Application No.: US13382876Application Date: 2010-06-29
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Publication No.: US09308258B2Publication Date: 2016-04-12
- Inventor: Gunasekaran Kannan , Hongxing Zhou
- Applicant: Gunasekaran Kannan , Hongxing Zhou
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Nathan A. Machin
- International Application: PCT/US2010/040471 WO 20100629
- International Announcement: WO2011/005621 WO 20110113
- Main IPC: C12N15/13
- IPC: C12N15/13 ; C12N15/63 ; A61K39/395
Abstract:
The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.
Public/Granted literature
- US20120116057A1 DESIGN OF STABLE AND AGGREGATION FREE ANTIBODY FC MOLECULES THROUGH CH3 DOMAIN INTERFACE ENGINEERING Public/Granted day:2012-05-10
Information query
IPC分类:
