Invention Grant
- Patent Title: Heterodimers of glutamic acid
- Patent Title (中): 谷氨酸的异二聚体
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Application No.: US13271549Application Date: 2011-10-12
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Publication No.: US09309193B2Publication Date: 2016-04-12
- Inventor: John W. Babich , Craig N. Zimmerman , Kevin P. Maresca
- Applicant: John W. Babich , Craig N. Zimmerman , Kevin P. Maresca
- Applicant Address: US MA Cambridge
- Assignee: Molecular Insight Pharmaceuticals, Inc.
- Current Assignee: Molecular Insight Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: K&L Gates LLP
- Main IPC: A61K51/04
- IPC: A61K51/04 ; A61K49/00 ; C07C275/24 ; C07B59/00 ; C07C275/16 ; C07C275/30 ; C07C311/19 ; C07D213/38

Abstract:
Compounds of Formula (Ia) wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or —NR′R′, Q is C(O), O, NR′, S, S(O)2, C(O)2 (CH2)p Y is C(O), O, NR′, S, S(O)2, C(O)2 (CH2)p Z is H or C1-C4 alkyl, R′ is H, C(O), S(O)2, C(O)2, a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl or a C1-C6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C6-C12 heteroaryl, —NR′R′ or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition. Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.
Public/Granted literature
- US20120269726A1 Heterodimers of Glutamic Acid Public/Granted day:2012-10-25
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