Invention Grant
US09309226B2 Crystalline form I of tyrosine kinase inhibitor dimaleate and preparation methods thereof
有权
酪氨酸激酶抑制剂二马来酸的结晶形式I及其制备方法
- Patent Title: Crystalline form I of tyrosine kinase inhibitor dimaleate and preparation methods thereof
- Patent Title (中): 酪氨酸激酶抑制剂二马来酸的结晶形式I及其制备方法
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Application No.: US14412762Application Date: 2013-06-04
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Publication No.: US09309226B2Publication Date: 2016-04-12
- Inventor: Piaoyang Sun , Guaili Wu , Bo Yuan , Yongjiang Chen
- Applicant: Jiangsu Hengrui Medicine Co., Ltd.
- Applicant Address: CN Lianyungang, Jiangsu
- Assignee: Jiangsu Hengrui Medicine Co., Ltd.
- Current Assignee: Jiangsu Hengrui Medicine Co., Ltd.
- Current Assignee Address: CN Lianyungang, Jiangsu
- Agency: Panitch Schwarze Belisario & Nadel LLP
- Priority: CN201210240697 20120712
- International Application: PCT/CN2013/076717 WO 20130604
- International Announcement: WO2014/008794 WO 20140116
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07C55/08
Abstract:
Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrrolidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof, and pharmaceutical compositions containing the same. The crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in the preparation of medicaments for treating diseases related to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.
Public/Granted literature
- US20150166511A1 CRYSTALLINE FORM I OF TYROSINE KINASE INHIBITOR DIMALEATE AND PREPARATION METHODS THEREOF Public/Granted day:2015-06-18
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