Invention Grant
US09309228B2 Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as a medicament and the preparation thereof
有权
9- [4-（3-氯-2-氟 - 苯基氨基）-7-甲氧基 - 喹唑啉-6-基氧基] -1,4-二氮杂 - 螺[5.5]十一烷-5-酮的富马酸盐，其用途 作为药物及其制备
![Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as a medicament and the preparation thereof](/docs/US/2016-04-12/US09309228B2/abs.jpg.600x600.jpg)
- Patent Title: Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as a medicament and the preparation thereof
- Patent Title (中): 9- [4-（3-氯-2-氟 - 苯基氨基）-7-甲氧基 - 喹唑啉-6-基氧基] -1,4-二氮杂 - 螺[5.5]十一烷-5-酮的富马酸盐，其用途 作为药物及其制备
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Application No.: US13944323Application Date: 2013-07-17
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Publication No.: US09309228B2Publication Date: 2016-04-12
- Inventor: Markus Ostermeier , Peter Sieger
- Applicant: Markus Ostermeier , Peter Sieger
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Edward S. Lazer
- Priority: EP12177040 20120719
- Main IPC: C07D403/12
- IPC: C07D403/12 ; A61K31/517 ; A61K45/06 ; C07C51/41 ; C07C57/15
![Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as a medicament and the preparation thereof](/abs-image/US/2016/04/12/US09309228B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a compound of formula (I), which has valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, processes for stereoselectively preparing these compounds, particularly pharmaceutical formulations suitable for inhalation and their use for the treatment of diseases, particularly tumoral diseases, benign prostatic hyperplasia and diseases of the lungs and airways.
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