Invention Grant
US09309288B2 Selective αvβ3 receptor peptide antagonist for therapeutic and diagnostic applications
有权
选择性αv＆bgr 3受体肽拮抗剂用于治疗和诊断应用
- Patent Title: Selective αvβ3 receptor peptide antagonist for therapeutic and diagnostic applications
- Patent Title (中): 选择性αv＆bgr 3受体肽拮抗剂用于治疗和诊断应用
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Application No.: US14016020Application Date: 2013-08-30
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Publication No.: US09309288B2Publication Date: 2016-04-12
- Inventor: Annarita Del Gatto , Laura Zaccaro , Carlo Pedone , Michele Saviano
- Applicant: ADVANCED ACCELERATOR APPLICATIONS
- Applicant Address: FR Saint Genis Pouilly
- Assignee: ADVANCED ACCELERATOR APPLICATIONS
- Current Assignee: ADVANCED ACCELERATOR APPLICATIONS
- Current Assignee Address: FR Saint Genis Pouilly
- Agency: Steinfl & Bruno LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/46 ; C07K7/64 ; C07K14/745
Abstract:
The present invention is related to new peptide antagonists of αvβ3 receptor, designed on the basis of the crystal structure of integrin αvβ3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the αvβ3 receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for αvβ3-targeted therapy and imaging.
Public/Granted literature
- US20140094412A1 SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS Public/Granted day:2014-04-03
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