Invention Grant
US09309291B2 Broad spectrum influenza A neutralizing vaccines and D-peptidic compounds, and methods for making and using the same
有权
广谱流感A中和疫苗和D-肽化合物,以及制备和使用它们的方法
- Patent Title: Broad spectrum influenza A neutralizing vaccines and D-peptidic compounds, and methods for making and using the same
- Patent Title (中): 广谱流感A中和疫苗和D-肽化合物,以及制备和使用它们的方法
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Application No.: US13691549Application Date: 2012-11-30
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Publication No.: US09309291B2Publication Date: 2016-04-12
- Inventor: Dana Ault-Riche , Maruti Uppalapati
- Applicant: Reflexion Pharmaceuticals , The Governing Council of the University of Toronto
- Applicant Address: US CA San Francisco CA Toronto
- Assignee: Reflexion Pharmaceuticals, Inc.,The Governing Council of the University of Toronto
- Current Assignee: Reflexion Pharmaceuticals, Inc.,The Governing Council of the University of Toronto
- Current Assignee Address: US CA San Francisco CA Toronto
- Agency: Bozicevic, Field & Francis LLP
- Agent Bret E. Field; Glenn J. Foulds
- Main IPC: C07K14/11
- IPC: C07K14/11 ; G01N33/68 ; G01N33/569 ; C07K14/005 ; A61K38/00

Abstract:
GB1 peptidic compounds that specifically bind to a hemagglutinin target protein, and libraries that include the same, as well as methods of making and using the same, are provided. Also provided are methods and compositions for making and using the compounds. Also provided are hemagglutinin mimics and fragments and methods of using the same, including methods of screening for GB1 peptidic compounds and methods of using conjugates the mimics as influenza A vaccines. Aspects of the invention include methods of screening libraries of L-peptidic compounds for specific binding to a D-peptidic hemagglutinin target protein. Once a L-peptidic compound has been identified that specifically binds to the D-peptidic hemagglutinin target protein, the D-enantiomer of the selected L-peptidic compound may be produced. In some embodiments, the D-enantiomer of the selected L-peptidic compound binds to, and in some instances, neutralizes influenza virus particles.
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