A tire temperature and tire pressure wireless sensing device is provided, which includes a housing, a valve body, a power supply module, a circuit board and a transmission antenna. The power supply module is disposed on the fixed seat of the housing, and the circuit board includes a wireless transmission module and a sensing module thereon. The sensing module is disposed corresponding to an air-intake through hole of the bottom seat of the housing. The valve body is engaged with the air-intake through hole and one end of the transmission antenna is disposed in an antenna slot.