A novel method of making a crystal block array (configured for coupling with photodetectors as part of an integrated detector module useful in advanced PET scanner systems) is disclosed herein. The novel method comprises a series of cutting, polishing, and assembling steps that utilize a curable bonding agent, removable wire spacers, and a series removable protective glass end plates. The crystal block arrays disclosed herein may be of various dimensions and geometries and are amenable to mass production.