A system for tracking identifying and detecting a tamper evident closure assembly for a pre-filled syringe, as well as multiple components associated therewith, along various points of a distribution route, including the location where the syringe is being accessed. A predetermined identifying code is applied to each or predetermined ones of a plurality of components of the same closure assembly in the form of electronically, visually or optically readable coded indicia. Alternatively, the predetermined identifying code can be one or more RFID structures each disposed on a predetermined one of the multiple components. The predetermined identifying code enables one to determine the identity and distinguish each of a plurality of closure assemblies and their multiple components from one another. The occurrence of tampering with a closure assembly can be accomplished by reading, detecting and/or comparing the predetermined identifying code on any of the multiple components of a closure assembly.