Invention Grant
US09314005B2 Genetically modified rat models for severe combined immunodeficiency (SCID)
有权
用于严重联合免疫缺陷（SCID）的转基因大鼠模型
- Patent Title: Genetically modified rat models for severe combined immunodeficiency (SCID)
- Patent Title (中): 用于严重联合免疫缺陷（SCID）的转基因大鼠模型
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Application No.: US13391307Application Date: 2010-07-01
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Publication No.: US09314005B2Publication Date: 2016-04-19
- Inventor: Eric M. Ostertag , John Stuart Crawford , Joseph Ruiz
- Applicant: Eric M. Ostertag , John Stuart Crawford , Joseph Ruiz
- Applicant Address: US KY Lexington
- Assignee: Transposagen Biopharmaceuticals, Inc.
- Current Assignee: Transposagen Biopharmaceuticals, Inc.
- Current Assignee Address: US KY Lexington
- Agency: Frost Brown Todd LLC
- International Application: PCT/US2010/040768 WO 20100701
- International Announcement: WO2011/002988 WO 20110106
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A01K67/033 ; A01K67/027 ; G01N33/00 ; C12N9/12 ; C12N9/14 ; C12N9/22 ; C12N15/85 ; C12N15/87 ; C12N15/90
Abstract:
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.
Public/Granted literature
- US20120177577A1 Genetically Modified Rat Models for Severe Combined Immunodeficiency (SCID) Public/Granted day:2012-07-12
Information query
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