Invention Grant
- Patent Title: Compositions and methods for the storage of red blood cells
- Patent Title (中): 用于储存红细胞的组合物和方法
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Application No.: US11060026Application Date: 2005-02-17
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Publication No.: US09314014B2Publication Date: 2016-04-19
- Inventor: John R. Hess , Tibor J. Greenwalt
- Applicant: John R. Hess , Tibor J. Greenwalt
- Applicant Address: US MD Baltimore US OH Cincinnati
- Assignee: University of Maryland, Baltimore,University of Cincinnati
- Current Assignee: University of Maryland, Baltimore,University of Cincinnati
- Current Assignee Address: US MD Baltimore US OH Cincinnati
- Agency: Sunstein Kann Murphy & Timbers LLP
- Main IPC: A01N1/02
- IPC: A01N1/02 ; C12N5/078
Abstract:
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.
Public/Granted literature
- US20050233302A1 Compositions and methods for the storage of red blood cells Public/Granted day:2005-10-20
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