Invention Grant
US09314485B2 Use of PI3K M-TOR and AKT inhibitors to induce FOXP3 expression and generate regulatory T cells
有权
使用PI3K M-TOR和AKT抑制剂诱导FOXP3表达并产生调节性T细胞
- Patent Title: Use of PI3K M-TOR and AKT inhibitors to induce FOXP3 expression and generate regulatory T cells
- Patent Title (中): 使用PI3K M-TOR和AKT抑制剂诱导FOXP3表达并产生调节性T细胞
-
Application No.: US14527044Application Date: 2014-10-29
-
Publication No.: US09314485B2Publication Date: 2016-04-19
- Inventor: Matthias Michael Merkenschlager
- Applicant: Medical Research Council
- Applicant Address: GB Swindon
- Assignee: MEDICAL RESEARCH COUNCIL
- Current Assignee: MEDICAL RESEARCH COUNCIL
- Current Assignee Address: GB Swindon
- Agency: McAndrews, Held & Malloy Ltd.
- Priority: GB0624999.9 20061214; GB0707609.4 20070419
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C12N5/0783 ; A61K35/12
Abstract:
The invention relates to a method of inducing Foxp3 expression in a T cell comprising (i) stimulating a T cell (ii) inhibiting signalling via PI3K alpha or PI3K delta or m-TOR or Akt in said T cell, wherein said inhibition is commenced 10 to 22 hours after the stimulation of (i). The invention also relates to certain uses of PI3K inhibitors, PI3K inhibitors for particular uses, and kits.
Public/Granted literature
- US20150147304A1 USE OF PI3K M-TOR AND AKT INHIBITORS TO INDUCE FOXP3 EXPRESSION AND GENERATE REGULATORY T CELLS Public/Granted day:2015-05-28
Information query
IPC分类:
