Invention Grant
- Patent Title: Arlethynyl derivatives
- Patent Title (中): 炔丙炔衍生物
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Application No.: US14085064Application Date: 2013-11-20
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Publication No.: US09315498B2Publication Date: 2016-04-19
- Inventor: Luke Green , Wolfgang Guba , Georg Jaeschke , Synese Jolidon , Lothar Lindemann , Antonio Ricci , Daniel Rueher , Heinz Stadler , Eric Vieira
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: HOFFMAN-LA ROCHE INC.
- Current Assignee: HOFFMAN-LA ROCHE INC.
- Current Assignee Address: US NJ Nutley
- Priority: EP10159754 20100413
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/501 ; A61K31/4965 ; A61K31/505 ; A61K31/44 ; C07D401/04 ; C07D401/14 ; C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D239/02 ; C07D471/04 ; C07D403/04 ; C07D413/04 ; C07D413/14 ; C07D498/04 ; C07D491/107 ; C07D241/02 ; C07D241/00
Abstract:
The present invention relates to ethynyl compounds of formula I-C1 wherein R1, R2, R2′, R3, R3′, R6, U, V and W are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof, which are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
Public/Granted literature
- US20140155602A1 Arlethynyl Derivatives Public/Granted day:2014-06-05
Information query
