An exemplary noise reduction system and method processes a speech signal that is delivered in a noisy channel or with ambient noise. Some exemplary embodiments of the system and method use filters to extract speech information, and focus on a subset of harmonics that are least corrupted by noise. Some exemplary embodiments disregard signal harmonics with low signal-to-noise ratio(s), and disregard amplitude modulations that are inconsistent with speech. An exemplary system and method processes a signal that focuses on a subset of harmonics that are least corrupted by noise, disregards the signal harmonics with low signal-to-noise ratio(s), and disregards amplitude modulations that are inconsistent with speech.