Apparatus and methods are disclosed for power control of uplink transmissions by a user equipment in a way that can reduce interference to neighbor cells. Various aspects of the disclosure decouple the power control for uplink data transmissions from the power control for uplink for a control channel transmissions. For example, one type of power control command may be utilized to control the power the UE utilizes to transmit data channels such as the DPDCH and/or the E-DCH (e.g., the E-DPDCH and the E-DPCCH). Further, another type of power control command may be utilized to control the power the UE utilizes to transmit control channels such as the HS-DPCCH. In this way, the uplink data channels, which can cause substantial interference to neighbor cells, can be power controlled by those neighbor cells to reduce that interference. Moreover, the control channel corresponding to the downlink data transmissions can be controlled by the downlink serving cell, thus ensuring reliable feedback corresponding to those downlink transmissions.