A method and apparatus for performing effective feedback in a wireless communication system supporting multiple antennas. A method for transmitting CSI of downlink transmission via uplink in a wireless communication system includes transmitting a joint-coded rank indicator (RI) and a first wideband (WB) precoding matrix indicator (PMI) at a first subframe, and transmitting a wideband channel quality indicator (WB CQI) and a second WB PMI at a second subframe. A user equipment (UE) preferred precoding matrix is indicated by a combination of the first PMI and the second PMI. If the RI is Rank-1 or Rank-2, the first PMI indicates one of subsets each having 8 indexes from among 16 indexes of the first PMI of a precoding codebook.