Invention Grant
US09320487B2 Method for estimating flow rates, pressure gradients, coronary flow reserve, and fractional flow reserve from patient specific computed tomography angiogram-based contrast distribution data
有权
用于根据患者特定计算机断层摄影血管造影剂的对比度分布数据估计流速，压力梯度，冠状动脉血流储备和分数流量储备的方法
- Patent Title: Method for estimating flow rates, pressure gradients, coronary flow reserve, and fractional flow reserve from patient specific computed tomography angiogram-based contrast distribution data
- Patent Title (中): 用于根据患者特定计算机断层摄影血管造影剂的对比度分布数据估计流速，压力梯度，冠状动脉血流储备和分数流量储备的方法
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Application No.: US13868697Application Date: 2013-04-23
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Publication No.: US09320487B2Publication Date: 2016-04-26
- Inventor: Rajat Mittal , Albert C. Lardo , Jung Hee Seo
- Applicant: The Johns Hopkins University
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Johns Hopkins Technology Ventures
- Main IPC: A61B5/05
- IPC: A61B5/05 ; A61B6/00 ; A61B6/03 ; A61B5/02 ; A61B5/00 ; A61B5/026 ; G06T7/00
Abstract:
An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.
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