Some embodiments are directed to medical devices, and methods for making and using the medical devices. An exemplary endoprosthesis includes an expandable tubular framework having a proximal end, a distal end, and a lumen extending therethrough. The tubular framework includes a number of interconnected biostable struts. The tubular framework has a proximal region extending distally from the proximal end to an intermediate location, and a distal region extending proximally from the distal end to the intermediate location. The distal region of the tubular framework is more flexible than the proximal region.