Invention Grant
US09320722B2 Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods
有权
醛脱氢酶ALDH3A1调节因子及相关治疗方法
- Patent Title: Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods
- Patent Title (中): 醛脱氢酶ALDH3A1调节因子及相关治疗方法
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Application No.: US14498618Application Date: 2014-09-26
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Publication No.: US09320722B2Publication Date: 2016-04-26
- Inventor: Thomas D. Hurley
- Applicant: Indiana University Research and Technology Corporation
- Applicant Address: US IN Indianapolis
- Assignee: Indiana University Research and Technology Corporation
- Current Assignee: Indiana University Research and Technology Corporation
- Current Assignee Address: US IN Indianapolis
- Agency: Quarles & Brady, LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P35/00 ; A61K31/145 ; A61K45/06 ; A61K31/167 ; A61K31/63 ; A61K31/635 ; A61K31/4184 ; A61K31/136 ; A61K31/381 ; A61K31/426 ; A61K31/4436 ; A61K31/4439 ; A61K31/4468 ; A61K31/5377 ; A61K31/5386 ; A61K31/553
Abstract:
Described herein are compositions and methods for the treatment of cancer, and in particular cancers characterized by a high level of ALD3H1 activity, which is associated with chemoresistance to cancer chemotherapeutic agents that are degraded by ALD3H1. The compositions described herein act as competitive inhibitors of ALD3H1 and thereby reduce breakdown of chemotherapeutics by this enzyme, and increase their efficacy for cancer treatment.
Public/Granted literature
- US20150202169A1 NOVEL REGULATORS OF ALDEHYDE DEHYDROGENASE ALDH3A1 AND RELATED THERAPEUTIC METHODS Public/Granted day:2015-07-23
Information query
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