Invention Grant
- Patent Title: Myeloid derived suppressor cell inhibiting agents
- Patent Title (中): 骨髓来源的抑制细胞抑制剂
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Application No.: US13166017Application Date: 2011-06-22
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Publication No.: US09320735B2Publication Date: 2016-04-26
- Inventor: Steven W. Dow , Angela J Henderson , Leah Mitchell
- Applicant: Steven W. Dow , Angela J Henderson , Leah Mitchell
- Applicant Address: US CO Fort Collins
- Assignee: Colorado State University Research Foundation
- Current Assignee: Colorado State University Research Foundation
- Current Assignee Address: US CO Fort Collins
- Agency: Cooley LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/39 ; A61K31/438 ; A61K31/4184 ; A61K31/42 ; A61K31/437 ; A61K31/5386 ; A61K39/395
Abstract:
Myeloid derived suppressor cell (MDSC) inhibitory agents and vaccine and/or adjuvant enhancers are provided. Improved vaccine treatment regimens employing these agents are also provided. Cancer vaccines and methods for inhibiting tumor growth and cancer metastases are also presented. The myeloid derived suppressor cell (MDSC) inhibiting agents are described as bisphosphonates (such as liposomal clodronate) and CCR2 inhibitors and/or CCR2 antagonists. Methods for enhancing antibody titer levels in response to an antigen of interest are also provided.
Public/Granted literature
- US20120156280A1 MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS Public/Granted day:2012-06-21
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