Invention Grant
US09320736B2 Zinc chelating agents for depleting XIAP and sensitizing tumor cells to apoptosis
有权
锌螯合剂用于消耗XIAP并使肿瘤细胞对凋亡敏感
- Patent Title: Zinc chelating agents for depleting XIAP and sensitizing tumor cells to apoptosis
- Patent Title (中): 锌螯合剂用于消耗XIAP并使肿瘤细胞对凋亡敏感
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Application No.: US14610044Application Date: 2015-01-30
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Publication No.: US09320736B2Publication Date: 2016-04-26
- Inventor: Alexander Kutikov , Vladimir Kolenko , Seth M. Cohen , Robert G. Uzzo , Ervin Teper
- Applicant: Institute for Cancer Research
- Agency: Stradley Ronon Stevens & Young, LLP
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61K38/19 ; A61K45/06 ; A61K31/4709
Abstract:
The invention provides zinc chelating agents and formulations thereof that deplete XIAP in cancer cells and sensitize the cells to apoptosis-inducing agents. The invention provides methods for sensitizing apoptosis-resistant cancer cells to apoptosis-inducing agents, as well as methods for treating a subject with a combined therapy of a zinc chelating agent and an apoptosis-inducing agent.
Public/Granted literature
- US20150147291A1 Zinc Chelating Agents for Depleting Xiap and Sensitizing Tumor Cells to Apoptosis Public/Granted day:2015-05-28
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