Invention Grant
- Patent Title: Therapeutic and diagnostic molecules
- Patent Title (中): 治疗和诊断分子
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Application No.: US13376304Application Date: 2010-06-04
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Publication No.: US09320755B2Publication Date: 2016-04-26
- Inventor: Jennifer Gamble , Mathew Vadas , Gregory Goodall , Jennifer Young
- Applicant: Jennifer Gamble , Mathew Vadas , Gregory Goodall , Jennifer Young
- Applicant Address: AU Camperdown AU Sydney AU Leichardt
- Assignee: CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY,UNIVERSITY OF SYDNEY,WENKART FOUNDATION
- Current Assignee: CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY,UNIVERSITY OF SYDNEY,WENKART FOUNDATION
- Current Assignee Address: AU Camperdown AU Sydney AU Leichardt
- Agency: Perkins Coie LLP
- Priority: AU2009902615 20090605
- International Application: PCT/AU2010/000698 WO 20100604
- International Announcement: WO2010/139026 WO 20101209
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/63 ; C12N15/79 ; C12N15/113 ; A61K31/7105
Abstract:
The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
Public/Granted literature
- US20120196925A1 Therapeutic and Diagnostic Molecules Public/Granted day:2012-08-02
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