Invention Grant
- Patent Title: Pulmonary administration of immunoglobulin single variable domains and constructs thereof
- Patent Title (中): 免疫球蛋白单可变结构域的肺部给药及其构建体
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Application No.: US13761554Application Date: 2013-02-07
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Publication No.: US09320792B2Publication Date: 2016-04-26
- Inventor: Marie-Paule Lucienne Armanda Bouche , Peter Vanlandschoot , Erwin Sablon , Erik Depla , Stefan De Buck , Xavier Saelens , Bert Schepens , Karen Silence , Mark Vaeck , Paul M. P. Van Bergen En Henegouwen , Hans De Haard
- Applicant: Ablynx N.V.
- Applicant Address: BE Zwijnaarde
- Assignee: Ablynx N.V.
- Current Assignee: Ablynx N.V.
- Current Assignee Address: BE Zwijnaarde
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: EP03447005 20030110; WOPCT/EP2003/006581 20030623; WOPCT/EP2003/007313 20030708
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; C07K16/24 ; C07K16/28 ; C07K16/36 ; C07K16/40 ; C07K16/42 ; C07K16/10 ; A61K39/00
Abstract:
In one aspect, the invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further a method for delivering therapeutic molecules to the interior of cells. The invention further relates to anti-IgE therapeutic molecules.In one aspect, the present invention relates to a method wherein an immunoglobulin single variable domain (such as a Nanobody) and/or construct thereof are absorbed in pulmonary tissue. More particularly, the invention provides systemic delivery of an immunoglobulin single variable domain and/or construct thereof via the pulmonary route.
Public/Granted literature
- US20130136744A1 PULMONARY ADMINISTRATION OF IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND CONSTRUCTS THEREOF Public/Granted day:2013-05-30
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