Invention Grant
US09320793B2 Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
有权
治疗与淀粉样β1-42的可溶性低聚物种相关的疾病的方法
- Patent Title: Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
- Patent Title (中): 治疗与淀粉样β1-42的可溶性低聚物种相关的疾病的方法
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Application No.: US13693362Application Date: 2012-12-04
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Publication No.: US09320793B2Publication Date: 2016-04-26
- Inventor: William F. Goure , Franz F. Hefti , Renee C. Gaspar , Paul J. Shughrue , Fubao Wang , Weirong Wang , Ningyan Zhang , Wei-Qin Zhao , Alexander McCampbell , Min Xu
- Applicant: Acumen Pharmaceuticals, Inc. , Merck Sharp & Dohme Corp.
- Applicant Address: US CA Livermore US NJ Rahway
- Assignee: Acumen Pharmaceuticals, Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Acumen Pharmaceuticals, Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: US CA Livermore US NJ Rahway
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; A61K45/06 ; A61K39/00
Abstract:
This invention is a method and kit for treating a disease associated with, or resulting from, the accumulation of soluble oligomer amyloid beta 1-42 using an antibody, or antibody fragment thereof, that has a higher affinity for amyloid beta 1-42 oligomers than for amyloid beta 1-42 monomer, amyloid beta 1-40 monomer, plaques and amyloid beta fibrils and, optionally, a tau therapeutic or an inhibitor of amyloid beta production or aggregation.
Public/Granted literature
- US20130089537A1 METHOD FOR TREATING A DISEASE ASSOCIATED WITH SOLUBLE, OLIGOMERIC SPECIES OF AMYLOID BETA 1-42 Public/Granted day:2013-04-11
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