Invention Grant
US09320809B2 Nanoparticle comprising hydrophobic drug conjugated to cationic polymer and hydrophilic drug conjugated to anionic polymer
有权
包含与阳离子聚合物缀合的疏水性药物和与阴离子聚合物缀合的亲水药物的纳米粒子
- Patent Title: Nanoparticle comprising hydrophobic drug conjugated to cationic polymer and hydrophilic drug conjugated to anionic polymer
- Patent Title (中): 包含与阳离子聚合物缀合的疏水性药物和与阴离子聚合物缀合的亲水药物的纳米粒子
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Application No.: US14629732Application Date: 2015-02-24
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Publication No.: US09320809B2Publication Date: 2016-04-26
- Inventor: Seungjoo Haam , Yong-min Huh , Ilkoo Noh , Jihye Choi , Hyun-Ouk Kim , Dayeon Yun
- Applicant: University-Industry Foundation, Yonsei University
- Applicant Address: KR
- Assignee: University-Industry Foundation, Yonsei University
- Current Assignee: University-Industry Foundation, Yonsei University
- Current Assignee Address: KR
- Agency: Cooley LLP
- Agent Matthew Pavao
- Priority: KR10-2014-0094169 20140724
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/51 ; A61K47/48 ; A61K31/7068 ; A61K31/337
Abstract:
The present invention relates to a nanoparticle including a hydrophobic drug conjugated to a cationic polymer and a hydrophilic drug conjugated to an anionic polymer, a method of preparing the same and a pharmaceutical use thereof. The nanoparticle according to an embodiment of the present invention may deliver the hydrophilic drug and the hydrophobic drug at the same time, and may control an initial drug burst. Further, the nanoparticle according to an embodiment of the present invention is specific to a cancer cell environment, and thus selective diagnosis or treatment of cancer cells is possible.
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