Invention Grant
- Patent Title: HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
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Application No.: US14067858Application Date: 2013-10-30
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Publication No.: US09320810B2Publication Date: 2016-04-26
- Inventor: Erkki Ruoslahti , Kimmo Porkka , Sven Christian
- Applicant: Sanford-Burnham Medical Research Institute
- Applicant Address: US CA La Jolla
- Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee Address: US CA La Jolla
- Agent Krista P. Kauppinen; E. Stewart Mittler
- Main IPC: C07K5/00
- IPC: C07K5/00 ; A61K47/48 ; C07K14/47 ; C07K7/06
Abstract:
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided.
Public/Granted literature
- US20150031851A1 HMGN2 PEPTIDES AND RELATED MOLECULES THAT SELECTIVELY HOME TO TUMOR BLOOD VESSELS AND TUMOR CELLS Public/Granted day:2015-01-29
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