Invention Grant
- Patent Title: Hyperforin analogs, methods of synthesis, and uses thereof
- Patent Title (中): Hyperforin类似物，合成方法及其应用
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Application No.: US14123255Application Date: 2012-06-01
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Publication No.: US09321713B2Publication Date: 2016-04-26
- Inventor: Matthew D. Shair , Brian A. Sparling , David Moebius
- Applicant: Matthew D. Shair , Brian A. Sparling , David Moebius
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2012/040379 WO 20120601
- International Announcement: WO2012/167021 WO 20121206
- Main IPC: A61K31/122
- IPC: A61K31/122 ; C07C49/29 ; C07C49/753 ; C07C49/733 ; C07C49/743 ; C07C45/29 ; C07D493/08 ; C07F7/08 ; C07F7/18
Abstract:
The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.
Public/Granted literature
- US20140135287A1 HYPERFORIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF Public/Granted day:2014-05-15
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