Invention Grant
- Patent Title: Pyridine derivatives as agonists of the CB2 receptor
- Patent Title (中): 吡啶衍生物作为CB2受体的激动剂
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Application No.: US13486057Application Date: 2012-06-01
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Publication No.: US09321727B2Publication Date: 2016-04-26
- Inventor: Caterina Bissantz , Uwe Grether , Paul Hebeisen , Atsushi Kimbara , Qingping Liu , Matthias Nettekoven , Marco Prunotto , Stephan Roever , Mark Rogers-Evans , Tanja Schulz-Gasch , Christoph Ullmer , Zhiwei Wang , Wulun Yang
- Applicant: Caterina Bissantz , Uwe Grether , Paul Hebeisen , Atsushi Kimbara , Qingping Liu , Matthias Nettekoven , Marco Prunotto , Stephan Roever , Mark Rogers-Evans , Tanja Schulz-Gasch , Christoph Ullmer , Zhiwei Wang , Wulun Yang
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Priority: WOPCT/CN2011/075606 20110610
- Main IPC: C07D211/68
- IPC: C07D211/68 ; C07D211/80 ; C07D213/02 ; C07D401/00 ; C07D419/00 ; C07D417/00 ; C07D405/00 ; C07D213/62 ; C07D213/78 ; C07D211/78 ; C07D211/90 ; C07D213/81 ; C07D401/04 ; C07D401/14 ; C07D405/04 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D409/14 ; C07D413/12 ; C07D413/14 ; C07D417/06 ; C07D417/12 ; C07D491/107
Abstract:
The invention relates to a compound of formula (I) Wherein R1, R2, R3 and R4 are defined as in the description and in the claims. The said compounds of the invention are preferential agoniste of the Carsonabinocid Receptor 2 and thus useful as medicaments and may be used in treatment of chronic pain, atherosclerosis, ischemic/reperfusion injury and other related diseases.A representative compound of this invention is 6-cyclopropylmethoxy-5-(tetrahydro-pyradine-2-carboxglic acid [1-methyl-1-(5-methyl-(1,2,4]oxadiazol-3-yl)-ethyl)-amide.
Public/Granted literature
- US09290451B2 Pyridine derivatives as agonists of the CB2 receptor Public/Granted day:2016-03-22
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