Invention Grant
- Patent Title: Azole compounds as PIM inhibitors
- Patent Title (中): 唑类化合物作为PIM抑制剂
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Application No.: US14006285Application Date: 2012-03-21
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Publication No.: US09321756B2Publication Date: 2016-04-26
- Inventor: Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L. M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
- Applicant: Hui-Ling Wang , Victor J. Cee , Bradley J. Herberich , Claire L. M. Jackson , Brian Alan Lanman , Thomas Nixey , Liping H. Pettus , Anthony B. Reed , Bin Wu , Ryan Wurz , Andrew Tasker
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- International Application: PCT/US2012/029997 WO 20120321
- International Announcement: WO2012/129338 WO 20120927
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D487/04 ; C07D417/04 ; C07D471/04 ; C07D417/14 ; A61P35/00 ; A61P35/02 ; A61P35/04
Abstract:
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
Public/Granted literature
- US20140187553A1 Azole Compounds as PIM Inhibitors Public/Granted day:2014-07-03
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