Invention Grant
US09321782B2 Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties
有权
具有抗增殖性能的新型42-O-（杂烷氧基烷基）雷帕霉素化合物的制备方法
- Patent Title: Process for preparation of novel 42-O-(heteroalkoxyalkyl) rapamicin compounds with anti-proliferative properties
- Patent Title (中): 具有抗增殖性能的新型42-O-（杂烷氧基烷基）雷帕霉素化合物的制备方法
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Application No.: US13814174Application Date: 2011-08-02
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Publication No.: US09321782B2Publication Date: 2016-04-26
- Inventor: Dhananjay Sharad Rane , Rajnikant Gandalal Vyas , Pramod Kumar Minocha
- Applicant: Dhananjay Sharad Rane , Rajnikant Gandalal Vyas , Pramod Kumar Minocha
- Applicant Address: IN Gujarat
- Assignee: MERIL LIFE SCIENCES PVT. LTD.
- Current Assignee: MERIL LIFE SCIENCES PVT. LTD.
- Current Assignee Address: IN Gujarat
- Agency: Kramer & Amado, P.C.
- Priority: IN299/MUM/2010 20100804
- International Application: PCT/IN2011/000508 WO 20110802
- International Announcement: WO2012/017449 WO 20120209
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D491/18 ; A61K31/436 ; C07D498/18 ; A61M25/10
Abstract:
The invention discloses novel 42-0-(heteroalkoxyalkyl) rapamycin compounds of formula (1) and process for preparation thereof. These compounds are useful in the treatment of hyperproliferative vascular diseases such as restenosis and atherosclerosis Wherein, R denotes 3, 4 and 5 membered 3-hydroxy heteroalkoxyalkyl compounds selected from Tetrahydrofuran-3-ol, Oxetan-3-ol, Tetrahydropyran-3-ol, Tetrahydro-4- methyl furan-3-ol, Tetrahydro-2,5,5-trimethyl furan-3-ol, Tetrahydro-2,5-diethyl-2-methyl furan-3-ol, Tetrahydro-6-methoxy-2-methyl 2H-Pyran-3-ol and Tetrahydro-2,2-dimethyl-6-phenyl 2H-Pyran-3-ol.
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