Invention Grant
- Patent Title: Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
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Application No.: US14627960Application Date: 2015-02-20
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Publication No.: US09321799B2Publication Date: 2016-04-26
- Inventor: Thazha P. Prakash , Punit P. Seth , Eric E. Swayze
- Applicant: Ionis Pharmaceuticals, Inc.
- Applicant Address: US CA Carlsbad
- Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee: Ionis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: McNeill Baur PLLC
- Main IPC: C07H19/00
- IPC: C07H19/00 ; C07H21/02 ; C07H19/10 ; C07H19/067 ; C07H19/167 ; C07H19/20 ; C07H21/00 ; C12N15/113

Abstract:
The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides and analogs thereof that are useful for incorporation at the terminus of an oligomeric compound. Such oligomeric compounds can also be included in a double stranded composition. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
Public/Granted literature
- US20150159163A1 MODIFIED NUCLEOSIDES, ANALOGS THEREOF AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM Public/Granted day:2015-06-11
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