Invention Grant
- Patent Title: N-terminal modified PEG-TRAIL
- Patent Title (中): N-末端修饰的PEG-TRAIL
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Application No.: US12304121Application Date: 2007-06-12
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Publication No.: US09321825B2Publication Date: 2016-04-26
- Inventor: Kang Choon Lee , Su Young Chae , Yu Seok Youn , Won Bae Kim , Sung Kwon Lee
- Applicant: Kang Choon Lee , Su Young Chae , Yu Seok Youn , Won Bae Kim , Sung Kwon Lee
- Applicant Address: US MD Elkridge
- Assignee: Theraly Pharmaceuticals Inc.
- Current Assignee: Theraly Pharmaceuticals Inc.
- Current Assignee Address: US MD Elkridge
- Agency: Pabst Patent Group LLP
- Priority: KR1020060052702 20060612
- International Application: PCT/KR2007/002825 WO 20070612
- International Announcement: WO2007/145457 WO 20071221
- Main IPC: C07K14/52
- IPC: C07K14/52 ; C07K14/525 ; A61K38/19 ; A61K47/48 ; C07K14/705
Abstract:
Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.
Public/Granted literature
- US20090203599A1 N-TERMINAL MODIFIED PEG-TRAIL, METHOD FOR PREPARING AND USES THEREOF Public/Granted day:2009-08-13
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